Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
Identifieur interne : 005159 ( Main/Exploration ); précédent : 005158; suivant : 005160Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
Auteurs : Birgit Morgenstern [Allemagne] ; Martin Michaelis [Allemagne] ; Patrick C. Baer [Allemagne] ; Hans W. Doerr [Allemagne] ; Jindrich Cinatl [Allemagne]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (administration et posologie), Cellules Caco-2, Cellules Vero, Humains, Interféron bêta (administration et posologie), Lignée cellulaire, Rein (), Rein (virologie), Relation dose-effet des médicaments, Ribavirine (administration et posologie), Réplication virale (), Réplication virale (physiologie), Spécificité d'espèce, Synergie des médicaments, Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- administration et posologie : Antiviraux, Interféron bêta, Ribavirine.
- physiologie : Réplication virale, Virus du SRAS.
- virologie : Rein.
- Animaux, Cellules Caco-2, Cellules Vero, Humains, Lignée cellulaire, Rein, Relation dose-effet des médicaments, Réplication virale, Spécificité d'espèce, Synergie des médicaments, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (administration & dosage), Caco-2 Cells, Cell Line, Chlorocebus aethiops, Dose-Response Relationship, Drug, Drug Synergism, Humans, Interferon-beta (administration & dosage), Kidney (drug effects), Kidney (virology), Ribavirin (administration & dosage), SARS Virus (drug effects), SARS Virus (physiology), Species Specificity, Vero Cells, Virus Replication (drug effects), Virus Replication (physiology).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Interferon-beta, Ribavirin.
- drug effects : Kidney, SARS Virus, Virus Replication.
- physiology : SARS Virus, Virus Replication.
- virology : Kidney.
- Animals, Caco-2 Cells, Cell Line, Chlorocebus aethiops, Dose-Response Relationship, Drug, Drug Synergism, Humans, Species Specificity, Vero Cells.
Abstract
Initial in vitro investigations demonstrated type I interferons (IFNs: IFN-α, IFN-β) to inhibit replication of SARS coronavirus (SARS-CoV), but found the nucleoside analogue ribavirin ineffective in Vero cells. In this report, ribavirin was shown to inhibit SARS-CoV replication in five different cell types of animal or human origin at therapeutically achievable concentrations. Since clinical anti-SARS-CoV activity of type I interferons or ribavirin is limited, we investigated the combination of IFN-β and ribavirin. Determination of the virus yield indicated highly synergistic anti-SARS-CoV action of the combination suggesting the consideration of ribavirin plus IFN-β for the treatment of SARS.
Url:
DOI: 10.1016/j.bbrc.2004.11.128
PubMed: 15607755
PubMed Central: 7092851
Affiliations:
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Le document en format XML
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Doerr</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><affiliation wicri:level="3"><nlm:aff id="aff1">Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Str. 40, 60596 Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><series><title level="j">Biochemical and Biophysical Research Communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (administration & dosage)</term><term>Caco-2 Cells</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Drug</term><term>Drug Synergism</term><term>Humans</term><term>Interferon-beta (administration & dosage)</term><term>Kidney (drug effects)</term><term>Kidney (virology)</term><term>Ribavirin (administration & dosage)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (physiology)</term><term>Species Specificity</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term><term>Virus Replication (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (administration et posologie)</term><term>Cellules Caco-2</term><term>Cellules Vero</term><term>Humains</term><term>Interféron bêta (administration et posologie)</term><term>Lignée cellulaire</term><term>Rein ()</term><term>Rein (virologie)</term><term>Relation dose-effet des médicaments</term><term>Ribavirine (administration et posologie)</term><term>Réplication virale ()</term><term>Réplication virale (physiologie)</term><term>Spécificité d'espèce</term><term>Synergie des médicaments</term><term>Virus du SRAS ()</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-beta</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron bêta</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Kidney</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Réplication virale</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Rein</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Caco-2 Cells</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Dose-Response Relationship, Drug</term><term>Drug Synergism</term><term>Humans</term><term>Species Specificity</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Caco-2</term><term>Cellules Vero</term><term>Humains</term><term>Lignée cellulaire</term><term>Rein</term><term>Relation dose-effet des médicaments</term><term>Réplication virale</term><term>Spécificité d'espèce</term><term>Synergie des médicaments</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Initial in vitro investigations demonstrated type I interferons (IFNs: IFN-α, IFN-β) to inhibit replication of SARS coronavirus (SARS-CoV), but found the nucleoside analogue ribavirin ineffective in Vero cells. In this report, ribavirin was shown to inhibit SARS-CoV replication in five different cell types of animal or human origin at therapeutically achievable concentrations. Since clinical anti-SARS-CoV activity of type I interferons or ribavirin is limited, we investigated the combination of IFN-β and ribavirin. Determination of the virus yield indicated highly synergistic anti-SARS-CoV action of the combination suggesting the consideration of ribavirin plus IFN-β for the treatment of SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Vander Werf, S" uniqKey="Vander Werf S">S. vander Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. 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Sheng</name></author><author><name sortKey="Hsueh, P R" uniqKey="Hsueh P">P.R. Hsueh</name></author><author><name sortKey="Yang, C F" uniqKey="Yang C">C.F. Yang</name></author><author><name sortKey="Yang, P C" uniqKey="Yang P">P.C. Yang</name></author><author><name sortKey="Chang, S C" uniqKey="Chang S">S.C. Chang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Morgenstern, Birgit" sort="Morgenstern, Birgit" uniqKey="Morgenstern B" first="Birgit" last="Morgenstern">Birgit Morgenstern</name></region><name sortKey="Baer, Patrick C" sort="Baer, Patrick C" uniqKey="Baer P" first="Patrick C." last="Baer">Patrick C. Baer</name><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name><name sortKey="Doerr, Hans W" sort="Doerr, Hans W" uniqKey="Doerr H" first="Hans W." last="Doerr">Hans W. Doerr</name><name sortKey="Michaelis, Martin" sort="Michaelis, Martin" uniqKey="Michaelis M" first="Martin" last="Michaelis">Martin Michaelis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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